Heterozygous variant in WNT1 gene in two brothers with early onset osteoporosis
Osteoporosis is a multifactorial disorder characterized by low bone mass and strength, leading to increased risk of fracture.The WNT pathway plays a critical role in bone remodeling by enhancing osteoblastic differentiation, which promotes bone formation, and inhibiting osteoclastic differentiation, decreasing bone resorption.Therefore, Knives gene